The control of Ca2+ release from heart mitochondria.
نویسندگان
چکیده
منابع مشابه
The control of Ca2+ release from heart mitochondria.
Ca2+ release from heart mitochondria is induced by several agents which also release Ca2+ from liver mitochondria. Release induced by oxalacetate is accompanied by collapse of the membrane potential, swelling, proton uptake, inhibition of respiration, pyridine nucleotide oxidation, and loss of endogenous Mg2+ and K+ indicating that Caz+ depletion results from a nonspecific increase in inner mem...
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The efflux of Ca2+ from rat heart mitochondria has been examined by using Ruthenium Red to inhibit active uptake after predetermined loadings with Ca2+. The efflux is proportional to the internal Ca2+ load; it is increased by Na+ applied when the mitochondria are respiring and this effect is inhibited by oligomycin. The efflux of Ca2+ is diminished by ATP and by ADP, with the latter the more ef...
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Vesicular glutamate release from astrocytes depends on mobilization of free Ca(2+) from the endoplasmic reticulum (ER), and extracellular space to elevate cytosolic Ca(2+) (Ca(2+)(cyt)). Although mitochondria in neurons, and other secretory cells, have been shown to sequester free Ca(2+) and have been implicated in the modulation of Ca(2+)-dependent transmitter release, the role of mitochondria...
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15 صفحه اولPolyamines directly induce release of cytochrome c from heart mitochondria.
Cytochrome c release from mitochondria to the cytosol represents a critical step in apoptosis, correlated to the activation of the caspase cascade. In this report, we show that addition of micromolar concentrations of polyamines to isolated rat heart mitochondria induces the release of cytochrome c. Spermine, which is effective at concentrations of 10-100 microM, is more potent than spermidine,...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1981
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)69054-x